Some Principal Herbs:     Devadaru     Nimba     Mustaka     Bilva     Bitter Gourd

 
Insol-N
An Oral Ayurvedic
Anti-diabetic with a difference
Charges in INR Rs.620
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Testimonials & Opinions

 

  • INSOL-N is the drug of choice in keeping the blood sugar at normal level in 'Non insulin-dependent diabetes'.
  • Also found useful in 'Insulin-dependent diabetes', as it reduces the daily requirement of insulin dosage.
  • Does not cause hypo-glycaemic coma.
  • Reduces the chances of possible complications of diabetes like Diabetic Gangrene, Diabetic Neuropathy, Diabetic Retinopathy and the Vascular disease like Atherosclerosis.
 

INSOL-N Tablet creates a new dimension in the treatment of DIABETES. Being a research products INSOL-N is a combination of more than fourty anti-diabetic herbs, six 'bhasmas' and shilajith. It keeps the blood sugar at normal level and due to the presence of various bhasmas, it raises the body resistance which is usually reduced in diabetics which inturn makes them less susceptible to other infections. INSOL-N is absolutely safe and there is no risk of hypoglycemic coma.

IMPORTANT BENEFITS OF INSOL-N THERAPY

  • INSOL-N is drug of choice in keeping the blood sugar at normal level in 'Non insulin-dependent diabetes'. Even in 'Insulin-dependent diabetes', INSOL-N is found useful as it reduces the daily requirement of insulin dosage.
  • Above all, the chances of possible complications of diabetes like Diabetic Gangrene, Diabetic Neuropathy, Diabetic Retinopathy and the Vascular disease like Atherosclerosis will be significantly reduced by regular usage of INSOL-N by diabetics.

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SCIENTIFIC BACKGROUND

INSOL-N Tablet, is an oral Ayurvedic antidiabetic has undergone intensive research work. A post-graduate from Mangalore University in his research work induced diabetes or rats by injecting 'Alloxan' which destroys pancreas and subsequent administration of INSOL-N produced following results:

a) INSOL-N brings down the blood sugar to normal level within a short period.

b) Glycogen and protein levels in the tissues of the heart, liver and kidney are raised to normal level.

c) Lipid, cholesterol and tissue phosphates are brought down to normal level.

d) INSOL-N regenerates Beta cells of Islets of Langerhans of pancreas which secret body Insulin. The researcher got his M.Phil for the above work.

Another post-graduate from Mangalore University is doing Ph.D on INSOLI-N. An article was published in the souvenir released during the National Seminar on the role of Indigenous drug on diabetes mellitus held at Madras under the president ship of Dr.Sam G.P. Moses, Member, WHO Panel on Diabetes.

Diabetes Mellitus has been described in ancient ayurvedic texts under the name 'Prameha'. They have also explained in-detail the etiology for the disease and various herbal remedies for the same. The ayurvedic seers were aware of the genetic susceptibility and environmental factors responsbile for the disease.

According to the Modern Science, Diabetes Mellitus is a clinical syndrome characterised by hyperglycemia due to absolute or relative deficiency of Insulin. Lack of Insulin affects the metabolism of carbohydrate, protein, fat, water and electrolytes. If this state persists for long time, permanent and irreversible functional and structural changes in the cells of the body lead to the so-called complications of diabetes which affect the eye, the kidney and the nervous system.

Ayurveda, which advocates the holistic approach to the disease and advises the treatment in totality, plays an important role in controlling the blood sugar level at normal and preventing the complications of diabetes mellitus.

Insol-N, an ayurvedic medicine prepared by Muniyal Ayurvedic Research Centre, and tested on thousands of patients is one such medicine to treat Diabetes Mellitus, which has clinically proved to rejuvenate the cells of Panereas, hence helping the patient to live a healthy normal life.

Although diabetes is a disease with a very ancient history and has been extensively studied, its safe and truly satisfactory treatment continues to elude us. The incidence is increasing even in hither to less affected areas like developing countries and rural populations, where the prohibitive cost of currently followed treatment cannot be sustained.. As part of community health planning strategy, the search for locality available low cost medicine is on. As mentioned earlier there exist many scattered reports of orally used hypoglycemic drugs, based on both laboratory and clinical observations, but follow up is inadequate.

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COMPOSITION

Each 500 mg tablet contains the following Major Ingredients:

Eugenia Jambolan
Melia Azadirachta
Terminalia Chebula
Gymnema Sylvestre
Gentiana Kurroo
Helleborus niger
Emblica Officinalis
Terminalia Belerica
Curcuma Longa
Shuddha Guggul
Shilajith

Processed in the decoction of Pterocarpus marsupium(Asana), Acacia Catechu Khadira), Aegle marmelos (Bilwa), Memordica charantia (Karela - bitter gourd), Trigonella foenumgraecum (Methi), Azadirachta Indica (Nimba), Triphala, Sida Cordifolia (Bala), Tribulur terrestris (Gokharn), Ocimum sanctum (Tulasi)


DEVADARU

Botanical Name: Cedrus deodar

Family: Pinaceae

Habitat: Distributed in the Himalayas, in areas of elevation from 1,050-3,600m.

Botanical Description: A large handsome evergreen conifer tree reaching upto 85m in height, with almost rough, black, furrowed bark and spreading branches; shoots dimorphic.

The heartwood of deodar is light yellowish-brown, turning brown on exposure. It is oily, fragrant and strong.

Leaves needle-like, triquetrous, sharp, pointed

Parts used: Leaves, heartwood, oil.

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NIMBA

Botanical Name: Melia Azadiracta

Family: Meliaceae

Habitat: Distributed throughout India, in deciduous forests, also widely cultivated.

Botanical Description: A medium to large sized tree, 15-20 m in height with a clear bole of 7.0m having grayish to dark grey tubercled bark.

Leaves, sub-opposite, serrate, very oblique at base
Flowers cream or yellowish white in axillary panicles, staminal tubes conspicuous, cylindrical.
Fruits one-seeded drupes with woody endocarp greenish yellow when ripe,

Parts used: Bark, leaves, flowers, seeds, oil

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MUSTAKA

Botanical Name: Cyperus rotundus

Family: Cyperaceae

Habitat: Distributed throughout India, as a weed in waste lands from sea level to 1,800 m.

Botanical Description: A perennial glabrous herb with elongate slender stolons bearing hard black fragrant tubers and triquetrous aerial stems.

Leaves numerous, narrowly linear, finely acuminate, flat, one nerved.

Parts used: Tubers

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BILVA

Botanical Name: Aegle marmelos

Family: Rutaceae

Habitat: Distributed throughout India, in dry forests, also cultivated.

Botanical Description: A medium sized armed deciduous tree upto 8.0m high with straight, sharp, axillary thorns and yellowish brown shallowly furrowed corky bark.

Leaves trifoliate, aromatic, alternate, leaflets ovate or ovate-laceolate

Parts used: Roots, leaves, fruits

The fruit roots of this plant have hypoglycemic activity.

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BITTER GOURD

Botanical Name: Cucumis trigonus

Family: Cucurbitaceae

Habitat: Distributed throughout India, in dry areas.

Botanical Description: A perennial scabrid monoecious tendrillar herb with slender angled stem.
Leaves deeply, palmately five lobed, scabrid on both sides

Parts used: Roots, fruits, seeds

The fruit of this plant is tonic, stomachic, stimulant, alternative. It contains a fixed oil, an insulin like peptide glycosides (momordiu & charanthin) and an alkaloid (mormordicine), the peptide is known to lower blood sugar level in blood & urine.

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Pharmacological Action of some Individual Ingredients

Asphaltum (Shilajith): It is a powerful tonic and alterative. it is one of the best drug in Ayurveda for the treatment of Ayurveda.

Prerocarpus marsupium (Asana): The heartwood of the free has hypoglycemic creation and it is used in ayurveda for the same since thousand of year.

Trigonella foenumgraecum (Indian Ferugrek): Seeds are demulcent, tonic, carminative astringent & aphrodisiac. The seed, have hypoglycemic and hypocholestrolemic activity. It is effective in reversing gluconeogenic cuzymel to normal values in liver & kidney.

Tribulus terrestris (Gokhru): It is cooling, demulcent, tonic & aphrodisiac. This is useful in correcting the erective dysfunetion of chronic diabetics.

Acasia catechu (Rakta Khadira): The bark of this plant is described in ayurveda as the one which reduces body fat. It is astringent and has wound healing properties

Sida cordifolia (Bala): It is a nervine tonic, and has antibacterial, antiviral activity. The rout bark to useful in the treatment of diabetic neuropathy.

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SUMMARY OF EXPERIMENTAL STUDIES

  • Experiment 1: Experimental diabetes was induced by alloxan in albino rats. Insol - an ayurvedic drug, was used therapeutically to control hyperglycemia in the diabetic animals. Al oxan diabetic rats were studied for the effect of Insol on biochemical and histological aspects.
  • Experiment 2: Oral administration of insol normalised the elevated blood glucose levels of the diabetic rate after two and four weeks of therapy.
  • Experiment 3: Oral glucose tolerance test was carried out in normal, treated normals, diabetics and diabetics controlled by Insol (Experiment 1 and 2), to check blood Glucose homeostasis after the therapeutic ragimen. The treated normals Showed hypoglycemic effects, while the diabetic animals under drug therapy showed significant reduction in blood glucose levels.

Figure: Oral Glucose Tolerance Test in Normal and Diabetic rats after Insol-N treatment.

  • Experiment 4: Glycogen and protein depletion observed in the diabetic rat tissue were reversed by Insol-N therapy.
Figures: Tissue Protein and Glycogen of normal and diabetic rats afetr Insol-N treatment.
  • Experiment 5: Enhanced lipid and cholesterol levels in the diabetic state was found to be markedly reduced after treatment.

Figures: Tissue Lipids & Cholesterol of normal and diabetic rats after Insol-N treatment.

  • Experiment 6: Pancreatic amylase activities were below normal in diabetic animals. Administration of Insol could elevate the enzyme levels, but not to normal levels.
Enzyme
Control
Diabetic

Diabetic under INSOL-N therapy

AMYLASE

(Milliunit/mg Protien)

671.94

+ -

7.46

*242.45

+ -

10.41

*572.79

+ -

15.35

Values given are mean + - SEM of seven animals in each group

*Variations are stastically significant at P<0.001

 

  • Experiment 7: Enhanced levels of tissue phosphates (acid and alkaline phosphates ) and tissue transaminases (alanine and aspartate transaminases) in the diabetic tissuses showed significant reduction after treatment.

Figures: Tissue Phosphatases in Insol-N treated rats.

Figures: Tissue Transaminases in Insol-N treated rats.

  • Experiment 8: Histological studies made in pancreas of diabetic rats showed islet cell degranulation and destruction of B cells. Regeneration of B-cells and increased islet cell mass was noted in the pancreas of diabetic rats after insol treatment.

Normal Rats

Under Treatment
After Treatment

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Clinical Studies

Hypoglycaemic action of Insol-N

A study on 60 NIDDM patients in the age group of 30-60 years was carried out on OPD Basis to evoluate the effect of Insol-N in controlling blood sugar and urine sugar levels. Insol-N tablets were administered at a dose of 2 tablets thrice daily and all the patients were regularly followed up at the end of 2nd, 4th, 6th week, and thereafter at monthly intervals till 6 months.

Among the above patients 26 patients were diagnosed for the first time and were not receiving my antidiabetic drug of the remaining 34 patients, 24 cases were on Glibenclamide (10mg/day) and 10 cases were taking phenformin (75 mg/day). Inspite of the above treatment their blood sugar was not under control.

All the other causes of hyperglycemia were ruled out and routine systemic examination and initial FBS & PPBS along with urine sugar were tested. Standard diabetic diet was prescribed to them and advised to continue their normal morning walk for 45 minutes.

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Indications

  • In Non-Insulin Dependant Diabetes Mellitus
  • As an adjuvant in IDDM along with Insulin therapy.
  • Diabetic neuropathy.
  • Diabetic nephropathy.


Side Effects: No major side-effects have been observed, even with prolonged treatment.

Dosage: In NIDDM: Initially 2 tablets thrice daily followed by a maintenance of 2 tablet twice daily.

In IDDM: 2 tablets twice daily along with insulin. When the blood sugar comes to normal dosage to be increased to 2 tablets thrice daily while consequenty trying to reduce Insulin dosage.

Presentation: In waterproof plastic container

Contents: 100 tablets

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